The acute effects of 3-nitropropionic acid on the behavior and spontaneous cortical electrical activity of rats

• Authors: A. Lukacs , A. Szabo , T. Vezer , A. Papp
• Languages of publication: EN

Abstracts

EN

In this study, the acute effect of 3-nitropropionic acid was investigated on open field and startle behavior of rats, and on their cortical electrical activity. Spontaneous locomotor activity, acoustic startle response, and pre-pulse inhibition of acoustic startle were measured in male Wistar rats (10 weeks old, 180?200 g body weight) after a single dose of 10 or 20 mg/kg i.p. 3-nitropropionic acid. After the behavioral tests, the rats were anaesthetized, and spontaneous cortical electrical activity was recorded. The vertical, horizontal and local open field performance showed dose-dependent deterioration in the rats treated with 3-nitropropionic acid. The number of ?noise-positive' startle responses showed non-significant changes, but the inhibition by pre-pulse was significantly reduced in the high dose animals. High dose also increased the proportion of low-frequencies in the cortical activity. 3-nitropropionic acid, known primarily to act in repeated doses (e.g., in animal models of Huntington's disease) had also some clear-cut acute effects on behavioral and electrophysiological parameters of the treated rats.

Keywords

EN

ACOUSTIC STARTLE RESPONSE; CORTICAL ACTIVITY; RAT; SPONTANEOUS OPEN FIELD ACTIVITY

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2006
• Volume: 66
• Issue: 3
• Pages: 227-234

Contributors

author

A. Lukacs

author

A. Szabo

author

T. Vezer

author

A. Papp

• Document Type: ARTICLE
• Publication order reference: Anita Lukacs, Department of Public Health, University of Szeged Faculty of Medicine, Dom ter 10., H-6720 zeged, Hungary