New strategies for application of plasmid and viral vectors in gene therapy
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The success of gene therapy depends on development of efficient and safe delivery vectors. Recently, significant progress has been achieved in application of various non-viral delivery methods and numerous modified viral vectors for experimental gene therapy. Some of those vectors have been also successfully used in clinical trials of gene therapy. Further progress in this still promising, although not-fulfilling all expectations, treatment is dependent on the careful evaluation of the modes of transgene delivery and regulation of transgene expression in the diseased tissues. In this review the current progress in development of some of the tools for therapeutic gene transfer is discussed.
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Alicja Jozkowicz, Zaklad Biotechnologii Medycznej, Wydzial Biochemii, Biofizyki i Biotechnologii, Uniwersytet Jagiellonski, ul. Gronostajowa 7, 31-271 Krakow, Poland