PL EN


Preferences help
enabled [disable] Abstract
Number of results
1996 | 56 | 1 | 267-279
Article title

Molecular biology of brain aging and neurodegenerative disorders

Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
A significant component of the aging process is genetically determined. Numerous theories of aging exist, many of which postulate the existence of "longevity genes". Recent advances in molecular biological and other techinques have allowed a significantly greater understanding of aging and age-related disease. This will be illustrated by four genetic and sporadic diseases: Alzheimer's disease (AD) and related disorders, transthyretin dementia, cerebral amyloid angiopathy-Icelandic type and scrapie related diseases. Alzheimer's disease (AD), the most common of this group, is the leading cause of dementia in Western countries. Recent genetic and biochemical studies have shown in involvement of at least four genes in the pathogenesis of AD. In early-onset familial AD mutations in the (beta)PP, S182 (presenilin 1) and STM2 (presenilin 2 or E5-1) genes have been found, while in the more common late-onset AD the presence of the apolipoprotein E4 isotype is a major risk factor. Genetic studies have also helped to elucidate the etiology of rarer cerebral amyloidoses such as the recently described Hungarian amyloidosis that is characterized by meningocerebrovascular amyloid deposition, with resultant dementia. This disease is linked to a mutation in the transthyretin gene. It is hoped that in the near future this increase in knowledge will allow the development of therapeutic approaches to slow the aging process.
Contributors
author
author
References
Document Type
proceeding
Publication order reference
T.Wisniewski
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-f3b98057-c386-3307-b158-e28e62a0c841
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.