Dilatation of the lateral part of the transverse fissure of the brain in Alzheimer's disease

• Authors: O. Narkiewicz , M. Leon , A. Convit , A.E. George , J. Wegiel , J. Morys , M. Bobinski , J. Colomb , D.C. Miller , H.M. Wisniewski
• Languages of publication: EN

Abstracts

EN

Post-morten MRI (magnetic resonance images) studies followed by histopathological examination were used to study the size and the shape of the <lateral part> of the <transverse fissure> of the <brain> in seven individuals with Alzheimer disease (AD) and five controls. Incontrol brains, the lateral part of the transverse fissure is a narrow cleft protruding laterally as choroid and hippocampal recesses. In AD-affected brains, the lateral part of the transverse fissure becomes a large subarachnoid space as a result of different degrees of atrophy of various hippocampal and parahippocampal structures. Our findings directly indicate the relationship between changes in the hippocampal and parahippocampal structures and the size of the lateral part of the transverse fissure. Sector CA1, the subiculum, the entorhinal cortex, and the parahippocampal isocortex are the most affected, whereas the dentate gyrus is much less affected. Adjacent thalamic structures, which are less vulnerable to the AD pathology, do not appear to contribute to transverse fissure changes. The size and the shape of the lateral part of the transverse fissure of the brain in AD reflect the atrophy of the hippocampus and parahippocampal structures.

Keywords

EN

ALZHEIMER DISEASE; HIPPOCAMPUS; TRANSVERSE FISSURE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1993
• Volume: 53
• Issue: 3
• Pages: 457-465

Contributors

author

O. Narkiewicz

author

M. Leon

author

A. Convit

author

A.E. George

author

J. Wegiel

author

J. Morys

author

M. Bobinski

author

J. Colomb

author

D.C. Miller

author

H.M. Wisniewski

• Document Type: article
• Publication order reference: O.Narkiewicz