The effect of angiotensin II and its fragments on post-alcohol impairment of learning and memory

• Authors: Konstanty Wisniewski , Maria Borawska , Halina Car
• Languages of publication: EN

Abstracts

EN

Angiotensin II (1-8) (A II) and its fragments: angiotensin III (2-8) (A III), angiotensin IV (3-8) (A IV), angiotensin V (4-8) (A V) and angiotensin VI (3-7) (A VI) accelerate acquisition of avoidance response and prolong their extinction. A II fragments are devoid classical A II activities such as the effects on blood pressure and thirst. Alcohol administered chronically (for 9 weeks) depresses the ability to retrieve and acquire avoidance responses. The investigated A II fragments counteract the post-alcohol impairment of learning and memory processes (A V being somewhat less active). Fragments A IV and A VI normalize the retrieval in offspring of mothers exposed to alcohol pre- and post-natally.

Keywords

EN

ALCOHOLIZATION; ANGIOTENSIN II; ANGIOTENSIN III-IV; LEARNING; MEMORY PROCESS; RAT OFFSPRING

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 1
• Pages: 23-29

Contributors

author

Konstanty Wisniewski

author

Maria Borawska

author

Halina Car

• Document Type: article