PL EN


Preferences help
enabled [disable] Abstract
Number of results
2007 | 55 | 4 | 247-259
Article title

Cancer-associated retinopathy in patients with breast carcinoma

Title variants
Languages of publication
EN
Abstracts
EN
Introduction: Cancer-associated retinopathy (CAR) is a paraneoplastic neurological syndrome resulting in progressive loss of vision and clinical signs of retinal degeneration. It is associated with various types of cancer and is also considered to be an autoimmune disorder that involves cross-reaction between autoantibodies and retinal proteins. The aim of this study was to establish whether immunoreactivity to retinal antigens (RAs) observed in patients with breast cancer is accompanied by any visual impairments. Materials and Methods: Sera of 295 patients with diagnosed breast cancer were screened for the presence of anti-RAs antibodies using immunoblotting. Cellular immunoreactivity to RAs present in retinal extracts and to purified recoverin and arrestin was determined by means of a lymphocyte proliferation assay. Six patients with high-titer antibodies to RAs then underwent ophthalmic and neurological examinations. Results: Four serum samples contained high-titer antibodies to a 46-kDa protein, most probably retinal ?-enolase, three had antibodies to a 48-kDa protein identified as retinal arrestin, while 56-, 43-, 41-, and 34-kDa antigens were recognized only by one serum sample each. Moreover, weak cellular response to all the RAs tested was observed in one patient and another patient responded only to retinal extract. Two of the examined patients displayed symptoms of CAR. Conclusions: Immunoreactivity to RAs in patients with breast cancer may also be present in cases without clinical signs of CAR.
Publisher

Year
Volume
55
Issue
4
Pages
247-259
Physical description
Contributors
References
Document Type
ARTICLE
Publication order reference
Patrycja Koszalka, Department of Medical Biotechnology, Division of Cell Biology, Intercollegiate Faculty of Biotechnology, Medical University of Gdansk, Debinki 1, 80-211 Gdansk, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-f27f4574-8165-3a41-b9d4-c4027b6e83c3
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.