Allergy is a complex genetic disorder contributing numerous genes, especially involved in Th2 immunity and IgE synthesis. Additional, environmental factors like: allergens exposure, cigarette smoke, pollutants, infectious agents and many others, have influence in allergy development. With DNA microarray technology it is possible to search for genes expression profiles of all interacting genes in pararel and learn more about the mechanism of allergy. These research include genes expression profiling of different model organisms (human, mice, monkey) and cell cultures.
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Micha? M. Sikorski, Instytut Chemii Bioorganicznej, Polska Akademia Nauk, ul. Noskowskiego 12/14, 61-704 Poznan, Poland