Axonal accumulation of p75NTR and TrkA in the septum following lesion of septo-hippocampal pathways
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Septal cholinergic neurones depend on trophic support by nerve growth factor (NGF) which can rescue them from injury-induced degeneration.Since NGF exerts its effects via p75NTR and TrkA receptors coexpressed in vast majority of these neurones and down-regulated without NGF treatment after injury.In this study we aimed to examine how does the lesion to the cholonergic tracts affect distribution of both type of receptor proteins in damaged fibres.Early changes (two and seven days) were examined immunocytochemically within the septum and supracallosal stria after unilateral lesion to the supracollosal area and cingulum transecting some septal cholinergic efferents.
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