Evaluation of interleukin-1 and -6 in the etiopathogenesis of idiopathic osteoporosis and osteopenia in children
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The aim of the study is to determine whether serum concentrations of interleukin (IL)-1 and IL-6 correlate with indices of bone mineral metabolism in children with idiopathic osteoporosis and osteopenia. The study comprised 62 patients aged 6?18 years (20 with idiopathic osteoporosis, 22 with idiopathic osteopenia, and 20 controls). In 10 children, investigations were repeated after one year of treatment. Serum concentrations of IL-1alpha, IL-1beta, IL-1 receptor antagonist (IL-1ra), as well as IL-6 and its soluble receptor (IL-6sR) were determined by the ELISA method. In patients with decreased bone mass, selected calcium-phosphorus metabolism indices and bone turnover markers were assessed. Higher values of IL-6 were recorded in those with idiopathic osteoporosis than in controls (2.79 vs. 1.43; p<0.05). In these patients there was also a tendency towards higher values of IL-6sR (p=0.05). IL-1alpha and IL-1beta were not markedly elevated in any of the patients. No significant differences between groups regarding IL-1ra were observed. Negative correlation between IL-6, IL-1alpha, cytokine/receptor indices, and spinal bone mineral density was determined. Positive correlation was found between IL-?, IL-1/IL-1ra, and parathormon as well as between IL-1?, IL-6sR, and bone formation markers. Increase in bone mass after treatment was accompanied by a decrease in IL-6sR. The higher serum levels of IL-6 in children with idiopathic osteoporosis/osteopenia and the decrease in IL-6sR after treatment reveal an involvement of IL-6 in the etiopathogenesis of these disturbances. The results suggest that IL-1 may also participate in the primary decrease of bone mass in children.
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Agnieszka Rusinska, Department of Pediatric Propedeutics and Metabolic Bone Diseases, Institute of Pediatrics, Medical University of Lodz, Poland