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Journal
2002 | 50 | 3-4 | 107-114
Article title

Transepithelial transport of sodium and chloride ions in isolated skin of the frog, Rana esculenta

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EN
Abstracts
EN
Isolated frog skin, mounted in a Ussing apparatus, was investigated electrophysiologically. Application of amiloride, an inhibitor of sodium ion transport, and bumetanide, known to block the transport of chloride ions, revealed the effect of these ions on PD, both under control conditions and following mechanical stimulation. Under control conditions, mechanical stimulation of the skin caused hyperpolarization, i.e. a transient increase in the electrical potential difference. Preincubation in the presence of amiloride, or amiloride plus bumetanide, brought about both a decrease in electrical potential and an inhibition of the reaction upon stimulation. On the other hand, incubation with bumetanide resulted in a decrease in electrical potential, but did not affect the skin reaction after mechanical stimulation. The above results indicate that hyperpolarization of the frog skin following mechanical stimulation is caused by enhanced transepithelial transport of sodium ions which, in turn, is induced by stimulation of sensory receptors.
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Contributors
References
Document Type
ARTICLE
Publication order reference
D. I. Kosik-Bogacka, Deparment of Biology and Medical Parasitology, Pomeranian Medical University, Powstancow Wielkopolskich 72, 70-111 Szczecin, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-ec0ec912-05a6-3111-b01b-a15dbad2ce82
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