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2006 | 54 | 6 | 393-401
Article title

Intracellular signaling pathways in IgE-dependent mast cell activation

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Languages of publication
EN
Abstracts
EN
Mast cells (MCs) are both central effectors and signaling cells in allergic reactions. Their key role in the immunopathology of asthma and other allergic diseases has been well documented. Molecular events leading to MC activation have not been yet fully established, however. Recent studies emphasize the key role of the protein tyrosine kinases Lyn and Fyn in MC signal transduction. The finding that Lyn kinase negatively regulates MC degranulation and that Fyn kinase enhances this effector response is of great importance. This creates new possibilities for therapeutic intervention in asthma and other allergic diseases. This review summarizes current knowledge on MC intracellular signaling and discusses the most recent strategies for the treatment of allergic diseases based on MC signaling pathway inhibition.
Publisher

Year
Volume
54
Issue
6
Pages
393-401
Physical description
Contributors
author
author
author
References
Document Type
REVIEW
Publication order reference
Agnieszka Kopec, M.D., Department of Internal Medicine and Allergology, Wroclaw Medical University, Traugutta 57/59, 50-417 Wroclaw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-ebd44de4-bef0-36bb-b3d6-336a2f69baac
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