Neutrophile activation by bacterial endotoxins
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The endotoxin (lipopolysaccharide, LPS), major component of Gram-negative bacteria cell wall, activate numerous types of cells, neutrophile included. The chemical compositions of polysaccharide (O-specific polysaccharide and core oligosaccharide) and hydrophobic lipid A parts of LPS are presented. The bindings of LPSs to neutrophiles resulted in signal transduction and neutrophiles activation. Neutrophiles, under LPS stimulation, generate oxygen radicals, nitric oxide and other components of inflammatory processes.
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W.Kaca, ul.Piotrkowska 182 m.564, 90-368 Lodz, Poland