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Journal
2006 | 2 | 65-88
Article title

50 years of studies of restriction ? modification systems

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Languages of publication
PL
Abstracts
EN
The basic function of restriction endonucleases and methyltransferases is protection of the host genome against foreign DNA. Their recombination and transposition related functions are still being discussed. Some authors postulate that R-M genes may act as selfish genetic elements. Restriction endonucleases are indispensable tools in molecular biology. As these enzymes recognize DNA sequence very specifically, they serve as a model for protein-DNA interaction. Restriction-modification genes have also played the same role as a model for evolutionary studies as well as protein structure - function relations. So far, there have been more than 3500 bacterial strains studied which possessed R-M genes of more than 280 different specificities towards recognition sequence and cleavage sites. They became a very good commercial product for many biotechnological companies. At present, in a genome sequencing era, R-M genes seem to be much more common than it was thought before.
Publisher

Journal
Year
Issue
2
Pages
65-88
Physical description
Contributors
author
author
References
Document Type
REVIEW
Publication order reference
Krzysztof Waleron, Katedra Biotechnologii, Miedzyuczelniany Wydzial Biotechnologii UG i AMG, ul. Kladki 24, 80-824 Gdansk, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-e9f7e0ee-3016-3c65-b513-4f3bdef6d46f
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