PL EN


Preferences help
enabled [disable] Abstract
Number of results
2007 | 55 | 2 | 91-98
Article title

Potential immunological functions of salivary Hsp70 in mucosal and periodontal defense mechanisms

Title variants
Languages of publication
EN
Abstracts
EN
Molecular chaperones were considered to be intracellular, but there is increasing evidence demonstrating their cytoprotective and immune modulator properties outside the cell. The major extracellular chaperone (Hsp70) was also found in saliva, indicating a possible effect of Hsp70 on mucosal surfaces. Here we summarize the immune-modulatory role of the 70-kDa stress protein family, with special attention on the potential impact of salivary Hsp70 on oral defense mechanisms. There are three major facets of Hsp70-induced immune activation: 1) the appearance of Hsp70 on the surface of certain tumor cells or virally infected cells, leading to their phagocytosis and subsequent lysis; 2) the role of extracellular uncomplexed Hsp70 as a danger signal, leading to the secretion of proinflammatory cytokines from antigen-presenting cells and T lymphocytes and of nitric oxide from macrophages as well as to complement activation; 3) receptor-mediated uptake of peptide-loaded Hsp70 to antigen-presenting cells and cross-presentation of the Hsp70-peptide complex as an antigen to cytotoxic T cells and natural killer lymphocytes. The immune-activating effect of salivary Hsp70 may also be highly important in oral defense, especially in areas where molecular and cellular participants of the immune response appear on the surface of the oral cavity (i.e. several lesions of the mucosa and the periodontal tissues).
Keywords
Publisher

Year
Volume
55
Issue
2
Pages
91-98
Physical description
Contributors
author
author
author
author
author
References
Document Type
REVIEW
Publication order reference
Tibor Karoly Fabian, Clinic of Prosthetic Dentistry, Faculty of Dentistry, Semmelweis University Budapest, Budapest, Hungary
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-e9ad3399-a2d5-3c96-abf8-4aa1dff2e038
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.