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2006 | 47 | 1 | 39?48
Article title

The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphism

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EN
Fatty acid-binding proteins (FABPs) are members of the superfamily of lipid-binding proteins (LBP). So far 9 different FABPs, with tissue-specific distribution, have been identified: L (liver), I (intestinal), H (muscle and heart), A (adipocyte), E (epidermal), Il (ileal), B (brain), M (myelin) and T (testis). The primary role of all the FABP family members is regulation of fatty acid uptake and intracellular transport. The structure of all FABPs is similar ? the basic motif characterizing these proteins is ?-barrel, and a single ligand (e.g. a fatty acid, cholesterol, or retinoid) is bound in its internal water-filled cavity. Despite the wide variance in the protein sequence, the gene structure is identical. The FABP genes consist of 4 exons and 3 introns and a few of them are located in the same chromosomal region. For example, A-FABP, E-FABP and M-FABP create a gene cluster. Because of their physiological properties some FABP genes were tested in order to identify mutations altering lipid metabolism. Furthermore, the porcine A-FABP and H-FABP were studied as candidate genes with major effect on fatness traits.
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47
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1
Pages
39?48
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ARTICLE
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Agata Chmurzynska, Department of Animal Genetics and Breeding, August Cieszkowski Agricultural University of Poznan, Poland
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bwmeta1.element.element-from-psjc-e88d36f7-a316-37b2-a4e0-7718f617b3b5
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