PL EN


Preferences help
enabled [disable] Abstract
Number of results
2008 | 56 | 1 | 15-30
Article title

Modulating the immune response by oral zinc supplementation: a single approach for multiple diseases

Content
Title variants
Languages of publication
EN
Abstracts
EN
Zinc is required for multiple cellular tasks, and especially the immune system depends on a sufficient availability of this essential trace element. During the last decades, many studies attempted to affect the outcome of various diseases by zinc supplementation. These efforts either aimed at supporting immunity by zinc administration or at correcting a loss of zinc secondary to the disease to restore the zinc-dependent functions of the immune system. This review aims to summarize the respective findings and to discuss possible molecular mechanisms by which zinc could influence viral, bacterial, and parasitic infections, autoimmune diseases, and the response to vaccination. Zinc supplementation in diseases such as diarrhea, chronic hepatitis C, shigellosis, leprosy, tuberculosis, pneumonia, acute lower respiratory infection, and leishmaniasis seems beneficial. In contrast, the results for the common cold and malaria are still not conclusive, and zinc was ineffective in most vaccination and rheumatoid arthritis studies. For AIDS and type 1 diabetes, zinc supplementation may even be a risk factor for increased mortality or deterioration of the glucose metabolism, respectively. In these cases, zinc supplementation should be used with care and limited to clearly zinc-deficient individuals.
Keywords
References
Document Type
REVIEW
Publication order reference
Hajo Haase, Institute of Immunology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
YADDA identifier
bwmeta1.element.element-from-psjc-e6faa33c-7357-35a1-83f1-a2f338b7348e
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.