EN
This article reviews the current concept in the ethiology and pathogenesis of systemic sclerosis. It is suggested that free radicals play a crucial role in pathomechanisms of scleroderma. In addition, the influence of some environmental agents (silica, bleomycin, aalcohol, toxic oil) on free radical production and subsequent induction of scleroderma or scleroderma-like syndrome is also described.