Immunoregulation of lymphoproliferation in vitro by monocytes and their subpopulations. II. Phenotypic changes of T cells in cultures activated with antigen and mitogen

• Authors: Janusz Pryjma , Danuta Kowalczyk , Irena Ruggiero , Marek Zembala
• Languages of publication: EN

Abstracts

EN

The aim of this study was to analyze phenotypes of T cells activated by mitogen (PWM) and antigen (PPD) in the presence of FcR+ or FcR- monocytes. It was found that CD4+ and CD8+ lymphocytes are preferentially acitvated in the presence of different <monocyte> subpopulations. Expression of HLA-DR and CD25 on CD4+ lymphocytes was greater in cultures activated in the presence of FcR-. CD8+ lymphocytes were more efficiently activated (exprression of HLA-DR) when FcR+ monocytes were added to culture. In the presence of FcR+ monocytes an increased expression of CD45RA antigen on CD4+ cells was also observed. These data support our previous functional studies which showed that "suppressor" T cells of CD8+ phenotype are activated in the presence of FcR+ monocytes.

Keywords

EN

ANTIGEN; IMMUNOREGULATION; LYMPHOPROLIFERATION; MITOGEN; MONOCYTE; T CELL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 1992
• Volume: 40
• Issue: 2
• Pages: 139-143

Contributors

author

Janusz Pryjma

author

Danuta Kowalczyk

author

Irena Ruggiero

author

Marek Zembala

• Document Type: article