PL EN


Preferences help
enabled [disable] Abstract
Number of results
2002 | 56 | 4 | 485-498
Article title

Nucleotide excision repair, NER - a relationship with cancer risk

Content
Title variants
Languages of publication
PL
Abstracts
EN
DNA damage repair, responsible for maintaining the genome integrity, plays a central role in cancer biology. Individual DNA repair capacity is genetically determined. Inherited defect in nucleotide excision repair (NER) genes leads to three distinct and extremely rare disorders: xeroderma pigmentosum, associated with high risk of skin cancer, Cockayne syndrome, and trichothiodystrophy. The recently identified common polymorphism in several NER genes may also influence a risk of cancer in general population. The review presents current knowledge about a role of genetic variation of NER genes in cancer predisposition.
Keywords
References
Document Type
ARTICLE
Publication order reference
D. Butkiewicz, Centrum Onkologii-Instytut im. M.Sklodowskiej-Curie, Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-e3692c21-1f77-31fc-a2d9-d88a922bae2f
Identifiers
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.