Nucleotide excision repair, NER - a relationship with cancer risk
Languages of publication
DNA damage repair, responsible for maintaining the genome integrity, plays a central role in cancer biology. Individual DNA repair capacity is genetically determined. Inherited defect in nucleotide excision repair (NER) genes leads to three distinct and extremely rare disorders: xeroderma pigmentosum, associated with high risk of skin cancer, Cockayne syndrome, and trichothiodystrophy. The recently identified common polymorphism in several NER genes may also influence a risk of cancer in general population. The review presents current knowledge about a role of genetic variation of NER genes in cancer predisposition.
Publication order reference
D. Butkiewicz, Centrum Onkologii-Instytut im. M.Sklodowskiej-Curie, Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland