Nucleotide excision repair, NER - a relationship with cancer risk

• Authors: D. Butkiewicz , M. Rusin , M. Pawlas , M. Czarny , M. Chorazy
• Languages of publication: PL

Abstracts

EN

DNA damage repair, responsible for maintaining the genome integrity, plays a central role in cancer biology. Individual DNA repair capacity is genetically determined. Inherited defect in nucleotide excision repair (NER) genes leads to three distinct and extremely rare disorders: xeroderma pigmentosum, associated with high risk of skin cancer, Cockayne syndrome, and trichothiodystrophy. The recently identified common polymorphism in several NER genes may also influence a risk of cancer in general population. The review presents current knowledge about a role of genetic variation of NER genes in cancer predisposition.

Keywords

EN

CANCER   DNA DAMAGE   REPAIR CAPACITY  

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International; Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2002
• Volume: 56
• Issue: 4
• Pages: 485-498
• Document Type: ARTICLE
• Publication order reference: D. Butkiewicz, Centrum Onkologii-Instytut im. M.Sklodowskiej-Curie, Wybrzeze Armii Krajowej 15, 44-101 Gliwice, Poland