Neutrophil recognition of bacterial DNA and Toll-like receptor 9-dependent and independent regulation of neutrophil function

• Authors: Kebir D. El_ , L. Jozsef , J.G. Filep
• Languages of publication: EN

Abstracts

EN

Neutrophils are essential for host defense and detect the presence of invading microorganisms through recognition of pathogen-associated molecular patterns. Among these receptors are Toll-like receptors (TLRs). Neutrophils express all known TLRs except for TLR3. TLR9, localized intracellularly, is to date the best characterized sensor for bacterial DNA, containing short sequences of unmethylated CpG motifs, though TLR9-independent intracellular DNA recognition mechanism(s) may also exist. Bacterial DNA has profound impact on neutrophil functions; it promotes neutrophil trafficking in vivo, induces chemokine expression, regulates expression of adhesion molecules, enhances phagocyte activity, and rescues neutrophils from constitutive apoptosis. TLR9 stimulation results in alterations in cellular redox balance, peroxynitrite formation, activation of the mitogen-activated protein kinase, PI3-kinase, and Jun N-terminal kinase pathways and/or nuclear factor ?B and AP-1. These features identify an important role for bacterial DNA and TLR9 signaling in the regulation of neutrophil functions that are critical for optimal expression as well as for resolution of the inflammatory response.

Keywords

EN

APOPTOSIS; BACTERIAL DNA; INFLAMMATION; NEUTROPHIL

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2008
• Volume: 56
• Issue: 1
• Pages: 41-53

Contributors

author

Kebir D. El_

author

L. Jozsef

author

J.G. Filep

• Document Type: REVIEW
• Publication order reference: Janos G. Filep, Research Center, Maisonneuve-Rosemont Hospital, 5415 boulevard de l?Assomption, Montreal, QC, Canada