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2003 | 57 | 1 | 67-90
Article title

Is the application of nitric oxide (NO) synthase inhibitors justified in the therapy of septic shock?

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Languages of publication
PL
Abstracts
EN
NO mediates many systemic reactions in humans and animals. It is produced by constitutive synthases (cNOS) and one inducible by cytokines and endotoxines (iNOS). We summarize, on the base of experimental and clinical data, the pathophysiological role of NO in septic shock as well as the effects of pharmacological application of NOS inhibitors. The analysed data show, that the contribution of NO to the pathomechanism of septic shock is rather heterogenous, therefore the clinical therapeutical application of selective iNOS inhibitors is impossible without adequate new monitoring tools.
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Publisher

Year
Volume
57
Issue
1
Pages
67-90
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Contributors
author
author
author
References
Document Type
ARTICLE
Publication order reference
G. Jonderko, Katedra i Oddzial Kliniczny Chorob Wewnetrznych Slaska Akademia Medyczna, ul. Edukacji 102, 43-100 Tychy, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-e193d28a-0310-3b68-b9ba-96f266892def
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