Molecular basis of dendritic arborization

• Authors: M. Urbanska , M. Blazejczyk , J. Jaworski
• Languages of publication: EN

Abstracts

EN

The pattern of dendritic branching along with the receptor and channel composition and density of synapses regulate the electrical properties of neurons. Abnormalities in dendritic tree development lead to serious dysfunction of neuronal circuits and, consequently, the whole nervous system. Not surprisingly, the complicated and multi-step process of dendritic arbor development is highly regulated and controlled at every stage by both extrinsic signals and intrinsic molecular mechanisms. In this review, we analyze the molecular mechanisms that contribute to cellular processes that are crucial for the proper formation and stability of dendritic arbors, in such distant organisms as insects (e.g. Drosophila melanogaster), amphibians (Xenopus laevis), and mammals.

Keywords

EN

CYTOSKELETON; DENDRITIC ARBOR; MEMBRANE; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2008
• Volume: 68
• Issue: 2
• Pages: 264-288

Contributors

author

M. Urbanska

author

M. Blazejczyk

author

J. Jaworski

• Document Type: REVIEW
• Publication order reference: J. Jaworski , International Institute of Molecular and Cell Biology, Warsaw, Poland