Interference of psychotropic drugs with the injuring action of ethanol on gastric mucosal barrier

• Authors: Janusz Mroczka , Ryszard Bilski , Anna Dziadus-Sokolowska , Andrzej Szlachcic , Katarzyna Sieppel-Maciejewska , Jozef Michalski
• Languages of publication: EN

Abstracts

EN

The aim of this study was to establish whether some psychotropic drugs applied to patients under influence of alcohol, may potentiate its damaging action on gastric mucosal barrier. A sensitive index of such damage is a decline of the potential difference (PD) across the stomach wall. The experiments were carried out on Wistar rats of either sex, anesthetized with urethane-chloralose. The PD values were assayed with an apolarization method. The investigated solutions were administered intragastrically by gavage. Ethanol at a concentration of 40% v/v depressed PD by 39%. The investigated psychotropic drugs did not change PD by themselves but given in combination with ethanol caused significant decline of PD: diazepam (0,4 mg/kg) by 58%, chlorpromazine (6,7 mg/kg) by 59%, imipramine (2 mg/kg) by 48%, amitryptyline (4mg/kg) by 49%, phenytoin (4 mg/kg) by 53%, pridinol (0,3 mg/kg) by 58%. Intragastric administration of water did not change PD. The results indicate that while psychotropic drugs given alone do not affect significantly the gastric mucosal barrier, they may potentiate the damaging action of ethanol on this barrier.

Keywords

EN

ETHANOL; PSYCHOTROPIC DRUG

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 1
• Pages: 67-74

Contributors

author

Janusz Mroczka

author

Ryszard Bilski

author

Anna Dziadus-Sokolowska

author

Andrzej Szlachcic

author

Katarzyna Sieppel-Maciejewska

author

Jozef Michalski

• Document Type: article