Recent views on Ca 2+ function and regulation of its concentration in the cell nuclei

• Authors: R. Bucki , J. Gorski
• Languages of publication: PL

Abstracts

EN

Ca 2+ is involved in the regulation of many events in the nucleus, such as gene expression, DNA replication, DNA repair, chromatin fragmentation in apoptosis, modulation of an intranuclear contractile system. In some cases, the function of Ca 2+ is mediated by calmodulin. However, the regulation of nucleoplasmic Ca 2+ concentration has not been explored throughly. The data discussed in this review show that the [Ca 2+]n may be regulated independently of that of cytosolic Ca 2+. IP3 and acid ADP-ribose are the major factors responsible for Ca 2+ release into the nucleus from perinuclear space.

Keywords

EN

CALCIUM; CALCIUM ION; CELL NUCLEI; CELL NUCLEUS

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Index Copernicus International
• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 2001
• Volume: 55
• Issue: 1
• Pages: 157-175

Contributors

author

R. Bucki

author

J. Gorski

• Document Type: ARTICLE
• Publication order reference: R. Bucki, Zaklad Fizjologii AM, ul. Mickiewicza 2c, 15-230 Bialystok, Poland