Recent views on Ca 2+ function and regulation of its concentration in the cell nuclei
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Ca 2+ is involved in the regulation of many events in the nucleus, such as gene expression, DNA replication, DNA repair, chromatin fragmentation in apoptosis, modulation of an intranuclear contractile system. In some cases, the function of Ca 2+ is mediated by calmodulin. However, the regulation of nucleoplasmic Ca 2+ concentration has not been explored throughly. The data discussed in this review show that the [Ca 2+]n may be regulated independently of that of cytosolic Ca 2+. IP3 and acid ADP-ribose are the major factors responsible for Ca 2+ release into the nucleus from perinuclear space.
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R. Bucki, Zaklad Fizjologii AM, ul. Mickiewicza 2c, 15-230 Bialystok, Poland