Signel pathways governing maturation and function of T-cells

• Authors: J. Matuszyk , L. Strzadala
• Languages of publication: PL

Abstracts

EN

Signals delivered through the b/gp33 (pre-TCR) and T-cell receptor ab control proliferation and differentiation of thymocytes at two distinct control points of T cell maturation. Interaction between T-cell receptor (TCR) and peptide/MHC complex induce signaling pathways leading to activation of T cell. Signal transduction involves CD3z phosphorylation by Lck tyrosine kinase and activation of ZAP-70 which regulates signaling pathways through PKC, Ca++ and Ras/Raf kinase cascade. Appropriate response of cell is preceded by integration of different signals in the nucleus.

Keywords

EN

T CELL RECEPTOR

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Journal: Postępy Higieny i Medycyny Doświadczalnej
• Year: 1997
• Volume: 51
• Issue: 4
• Pages: 351-365

Contributors

author

J. Matuszyk

author

L. Strzadala

• Document Type: article
• Publication order reference: J.Matuszyk, Instytut Immunologii i Terapii Doswiadczalnej PAN ul. R.Weigla 12, 53-114 Wroclaw, Poland