Signel pathways governing maturation and function of T-cells
Languages of publication
Signals delivered through the b/gp33 (pre-TCR) and T-cell receptor ab control proliferation and differentiation of thymocytes at two distinct control points of T cell maturation. Interaction between T-cell receptor (TCR) and peptide/MHC complex induce signaling pathways leading to activation of T cell. Signal transduction involves CD3z phosphorylation by Lck tyrosine kinase and activation of ZAP-70 which regulates signaling pathways through PKC, Ca++ and Ras/Raf kinase cascade. Appropriate response of cell is preceded by integration of different signals in the nucleus.
Publication order reference
J.Matuszyk, Instytut Immunologii i Terapii Doswiadczalnej PAN ul. R.Weigla 12, 53-114 Wroclaw, Poland