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1997 | 51 | 4 | 351-365
Article title

Signel pathways governing maturation and function of T-cells

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Languages of publication
PL
Abstracts
EN
Signals delivered through the b/gp33 (pre-TCR) and T-cell receptor ab control proliferation and differentiation of thymocytes at two distinct control points of T cell maturation. Interaction between T-cell receptor (TCR) and peptide/MHC complex induce signaling pathways leading to activation of T cell. Signal transduction involves CD3z phosphorylation by Lck tyrosine kinase and activation of ZAP-70 which regulates signaling pathways through PKC, Ca++ and Ras/Raf kinase cascade. Appropriate response of cell is preceded by integration of different signals in the nucleus.
Keywords
Year
Volume
51
Issue
4
Pages
351-365
Physical description
References
Document Type
article
Publication order reference
J.Matuszyk, Instytut Immunologii i Terapii Doswiadczalnej PAN ul. R.Weigla 12, 53-114 Wroclaw, Poland
YADDA identifier
bwmeta1.element.element-from-psjc-da63d02d-99de-3f4c-a611-52e248a345e4
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