Anti-apoptosis function of TNF-alpha in chronic lymphocytic leukemia: lessons from Crohn 's disease and the therapeutic potential of bupropion to lower TNF-alpha

• Authors: R.E. Kast , E.L. Altschuler
• Languages of publication: EN

Abstracts

EN

Crohn's disease and B cell chronic lymphocytic leukemia (CLL) share a common link in their pathologic mechanisms. Lymphocytes in both diseases fail to undergo apoptosis and die properly. That failure is partly due to increased signaling by tumor necrosis factor (TNF)-alpha, and their respective pathologies directly follow from this apoptosis failure. Bupropion is a commonly used generic antidepressant in clinical use for over a decade, and early evidence indicates it lowers TNF levels. This paper suggests the use of bupropion in CLL to lower TNF levels, which may thereby slow CLL disease course.

Keywords

EN

APOPTOSIS; CROHN'S DISEASE; ETANERCEPT; INFLAMMATION; INFLIXIMAB; LYMPHOCYTE; LYMPHOCYTIC LEUKEMIA

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2005
• Volume: 53
• Issue: 2
• Pages: 143-147

Contributors

author

R.E. Kast

author

E.L. Altschuler

• Document Type: REVIEW
• Publication order reference: Richard E. Kast, M.D., University of Vermont, VT 05401, USA