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2005 | 53 | 2 | 143-147
Article title

Anti-apoptosis function of TNF-alpha in chronic lymphocytic leukemia: lessons from Crohn 's disease and the therapeutic potential of bupropion to lower TNF-alpha

Title variants
Languages of publication
EN
Abstracts
EN
Crohn's disease and B cell chronic lymphocytic leukemia (CLL) share a common link in their pathologic mechanisms. Lymphocytes in both diseases fail to undergo apoptosis and die properly. That failure is partly due to increased signaling by tumor necrosis factor (TNF)-alpha, and their respective pathologies directly follow from this apoptosis failure. Bupropion is a commonly used generic antidepressant in clinical use for over a decade, and early evidence indicates it lowers TNF levels. This paper suggests the use of bupropion in CLL to lower TNF levels, which may thereby slow CLL disease course.
Publisher

Year
Volume
53
Issue
2
Pages
143-147
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
Richard E. Kast, M.D., University of Vermont, VT 05401, USA
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-d9f4d5c1-7da7-3735-8632-d4c9f1aa96f4
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