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2006 | 66 | 2 | 153-176
Article title

Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases

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Abstracts
EN
A critical role of mitochondrial dysfunction and oxidative damage has been implicated in etiopathology of many neurodegenerative disorders, as well as in normal aging. Alzheimer's and Parkinson's diseases are common devastating late-onset neurodegenerative disorders, associated with mitochondrial DNA variations, which are suggested to affect mitochondrial functions. This paper reviews the current knowledge on the inherited and somatic mtDNA variations in both conditions.
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Year
Volume
66
Issue
2
Pages
153-176
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Document Type
ARTICLE
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Aleksandra Maruszak, Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warszawa, Poland
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YADDA identifier
bwmeta1.element.element-from-psjc-d9dcb25b-cce9-31d5-ba0c-927a1cc6777e
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