Mitochondrial DNA in pathogenesis of Alzheimer's and Parkinson's diseases

• Authors: A. Maruszak , K. Gaweda-Walerych , I. Soltyszewski , C. Zekanowski
• Languages of publication: EN

Abstracts

EN

A critical role of mitochondrial dysfunction and oxidative damage has been implicated in etiopathology of many neurodegenerative disorders, as well as in normal aging. Alzheimer's and Parkinson's diseases are common devastating late-onset neurodegenerative disorders, associated with mitochondrial DNA variations, which are suggested to affect mitochondrial functions. This paper reviews the current knowledge on the inherited and somatic mtDNA variations in both conditions.

Keywords

EN

ALZHEIMER'S DISEASE; HAPLOGROUP; MITOCHONDRIAL DNA; NEURODEGENERATION; NUCLEOTIDE POLYMORPHISM; PARKINSON'S DISEASE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2006
• Volume: 66
• Issue: 2
• Pages: 153-176

Contributors

author

A. Maruszak

author

K. Gaweda-Walerych

author

I. Soltyszewski

author

C. Zekanowski

• Document Type: ARTICLE
• Publication order reference: Aleksandra Maruszak, Department of Neurodegenerative Disorders, Medical Research Center, Polish Academy of Sciences, Pawinskiego 5, 02-106 Warszawa, Poland