Extracellular ATP as a neurotransmitter: its role in synaptic plasticity in the hippocampus

• Authors: A. Wieraszko
• Languages of publication: EN

Abstracts

EN

Growing evidence indices that ATP may play a very important role in Long-Term Potentiation (LTP), a neurophysiological process that has been implicated in memory formation.LTP is an enhancement of synaptic strength induced by a specific pattern of high frequency stimulation, or by application of exogenous ATP.In the hippocampus LTP-inducing stimulation is accompanied by a massive Ca2+ -dependent release of ATP from presympatic terminals.Released extracellular ATP may either intract with numerous types of ATP receptors present on the neuronal surface, or serve as a substrate for ecto-protein phosphorylation.The results of combined electrophysiological and biochemical experiments indicate that participation of extracellular ATP in the ecto-protein phosphorylation process is most likely involved in the permanent amplification of the synaptic response in the hippocampus.

Keywords

EN

ATP; HIPPOCAMPUS; NEUROTRANSMISSION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 1996
• Volume: 56
• Issue: 2
• Pages: 637-648

Contributors

author

A. Wieraszko

• Document Type: article
• Publication order reference: A.Wieraszko