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The compounds activating adenosine system alleviated morphine withdrawal syndrome (the number of escape attempts and body shakes) in rats. Body shakes were decreased mostly by N-ethylcarboxamidoadenosine, cyclohexyladenosine, dipyridamole and 2-chloroadenosine, while R-phenylisopropyladenosine very strongly decreased the number of escape attempts. Adenosine receptor antagonists (caffeine and theophylline) increased the number of escape attempts in morphine-dependent rats. Caffeine (10 mg/kg), administered preventively, antagonized the ingibitory effects of adenosine analogs. These results suggest the existence of relation between opioid receptors and the adenosine system.
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1-9
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author
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article
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bwmeta1.element.element-from-psjc-d63e9272-4e51-3a8e-9341-d4b2eb33b3cb