In vitro cytostatic activity of some amino acid 4-N-substituted cytosines

• Authors: Boguslaw Hladon , Anna Sloderbach , Przemyslaw Radosh , Jaroslaw Spychala , Krzysztof Golankiewicz
• Languages of publication: EN

Abstracts

EN

Cytotoxicity of 22 amino acid 4-N-substitued cytosine derivatives was studied on KB and HeLa human tissue cultures. The secondary modification of tryptamine substituent seems to be a determining factor of the cytotoxic activity of 4-N-pyrimidinyl amino acids. The activity of the investigated compounds was inversely dependent on their solubility limited by the results of the solubility-activity relationship analysis.

Keywords

EN

AMINO ACID; CYTOSTATIC ACTIVITY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 1992
• Volume: 40
• Issue: 2
• Pages: 145-150

Contributors

author

Boguslaw Hladon

author

Anna Sloderbach

author

Przemyslaw Radosh

author

Jaroslaw Spychala

author

Krzysztof Golankiewicz

• Document Type: article