B cell development and primary immunodeficiencies with hypogammaglobulinemia

• Authors: S. Hokibara , K. Agematsu , A. Komiyama
• Languages of publication: EN

Abstracts

EN

The differentiation of B cells along the pathway of B cell development has been well characterized. In the bone marrow, the differentiation from pro-B cells to immature B cells can be defined by several surface antigens, such as a surrogate light chain. Immature B cells become mature B cells and then circulate in the peripheral blood as naive B cells. In the peripheral lymphoid tissues, naive B cells differentiate into memory B cells, which express the CD27 molecule, or plasma cells. Primary immunodeficiencies with hypogammaglobulinemia are caused by defects of the specific molecules which are needed for the B cell differentiation. Recent studies of the genes responsible for such immunodeficiencies have clarified B cell development as well as their pathogenesis. We discuss here the molecules affecting the B cell development and primary immunodeficiencies with hypogammaglobulinemia.

Keywords

EN

B CELL; DEVELOPMENT; HYPOGAMMAGLOBULINEMIA; IMMUNODEFICIENCY

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2000
• Volume: 48
• Issue: 4
• Pages: 267-271

Contributors

author

S. Hokibara

author

K. Agematsu

author

A. Komiyama

• Document Type: REVIEW
• Publication order reference: S. Hokibara, Department of Pediatrics, Shinshu University School of Medicine, Matsumoto 390-8621, Japan