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2000 | 48 | 4 | 267-271
Article title

B cell development and primary immunodeficiencies with hypogammaglobulinemia

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Languages of publication
EN
Abstracts
EN
The differentiation of B cells along the pathway of B cell development has been well characterized. In the bone marrow, the differentiation from pro-B cells to immature B cells can be defined by several surface antigens, such as a surrogate light chain. Immature B cells become mature B cells and then circulate in the peripheral blood as naive B cells. In the peripheral lymphoid tissues, naive B cells differentiate into memory B cells, which express the CD27 molecule, or plasma cells. Primary immunodeficiencies with hypogammaglobulinemia are caused by defects of the specific molecules which are needed for the B cell differentiation. Recent studies of the genes responsible for such immunodeficiencies have clarified B cell development as well as their pathogenesis. We discuss here the molecules affecting the B cell development and primary immunodeficiencies with hypogammaglobulinemia.
Publisher

Year
Volume
48
Issue
4
Pages
267-271
Physical description
Contributors
author
author
author
References
Document Type
REVIEW
Publication order reference
S. Hokibara, Department of Pediatrics, Shinshu University School of Medicine, Matsumoto 390-8621, Japan
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-d507943f-aec3-346e-a30b-434cb3132b4a
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