A simple, non-invasive method for the measurement of reserpine-induced tremor in rats
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A new, non invasive method for measuring reserpine induced tremor in rodents is described here. The test procedure is based on the piezo electric principle and was evaluated using the tremorogenic compound reserpine and the stereotypies inducing drug apomorphine. Whereas for reserpine an orderly and dose related increase in activity was observed, no such effect was detected with apomorphine. In order to further evaluate the test procedure, studies on the antagonism of reserpine induced tremor were also performed. Results from these studies indicated that the DA agonist lisuride, but not the S2-antagonist ritanserin, were able to antagonize the reserpine induced tremor in a dose related manner.
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T.F.Meert, Department of Neuropsychopharmacology, Janssen Research Foundation, 30 Turnhoutseweg St., B 2340 Beerse, Belgium