Journal
Article title
Authors
A. Sikorska
Traczyk Z. Traczyk
Z. Traczyk
Konopka L. Konopka
L. Konopka
Fiszer-Maliszewska L. Fiszer-Maliszewska
L. Fiszer-Maliszewska
Wojciechowska B. Wojciechowska
B. Wojciechowska
Pienkowska-Grela B. Pienkowska-Grela
B. Pienkowska-Grela
Rygier J. Rygier
J. Rygier
Woroniecka R. Woroniecka
R. Woroniecka
Witkowska A. Witkowska
A. Witkowska
Rusin M. Rusin
M. Rusin
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Languages of publication
Abstracts
Li-Fraumeni syndrome is a rare autosomal, dominant trait of diverse types of cancers in children and young adults, with a predominance of soft tissue sarcomas, osteosarcomas, brain tumours, adrenocortical and breast carcinomas, as well as leukaemias. We present a family with an unusual cancer history fulfilling the criteria of Li-Fraumeni syndrome. Mutational analysis of the p53 gene in constitutional DNA of several affected members of the family did not show any germline p53 defect. Cytogenetic studies did not reveal any structural aberrations.
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Issue
Pages
379-384
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References
Document Type
ARTICLE
Publication order reference
A. Sikorska, Institute of Haematology and Blood Transfusion, ul. Chocimska 5, 00-957 Warszawa, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-d3216424-c771-3f79-9a6a-db18ace35e6b