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Number of results
2001 | 49 | 4 | 279-284

Article title

Multi-functional roles of stat3 revealed by conditional gene targeting

Authors

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Languages of publication

EN

Abstracts

EN
Signal transducer and activator of transcription (STAT) is a family of transcription factors composed of seven members. Gene-targeted mice of each STAT family protein displayed defective responses to cytokines, demonstrating an important role in cytokine-mediated biological responses. However, unlike the mice lacking other STAT proteins, Stat3-deficient mice died during their early embryogenesis. Therefore, in an attempt to avoid the lethality and assess the role of Stat3 in cytokine-mediated functions in mouse adult tissues, conditional gene targeting utilizing a Cre-loxP system was achieved. By this method, Stat3 was disrupted in several types of tissue, including T cells, macrophages, skin, and mammary gland. Analyses of these Stat3-mutant mice revealed important roles of Stat3 in biological functions in each tissue.

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author
author

References

Document Type

REVIEW

Publication order reference

K. Takeda, Department of Host Defense, Research Institute for Microbial Diseases, and CRSET of Japan Science and Technology Corporation, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan

Identifiers

YADDA identifier

bwmeta1.element.element-from-psjc-d1fb1746-d8e9-36ec-8b9a-84fce80ef1a5
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