Multi-functional roles of stat3 revealed by conditional gene targeting
Languages of publication
Signal transducer and activator of transcription (STAT) is a family of transcription factors composed of seven members. Gene-targeted mice of each STAT family protein displayed defective responses to cytokines, demonstrating an important role in cytokine-mediated biological responses. However, unlike the mice lacking other STAT proteins, Stat3-deficient mice died during their early embryogenesis. Therefore, in an attempt to avoid the lethality and assess the role of Stat3 in cytokine-mediated functions in mouse adult tissues, conditional gene targeting utilizing a Cre-loxP system was achieved. By this method, Stat3 was disrupted in several types of tissue, including T cells, macrophages, skin, and mammary gland. Analyses of these Stat3-mutant mice revealed important roles of Stat3 in biological functions in each tissue.
Publication order reference
K. Takeda, Department of Host Defense, Research Institute for Microbial Diseases, and CRSET of Japan Science and Technology Corporation, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan