Multi-functional roles of stat3 revealed by conditional gene targeting

• Authors: K. Takeda , S. Akira
• Languages of publication: EN

Abstracts

EN

Signal transducer and activator of transcription (STAT) is a family of transcription factors composed of seven members. Gene-targeted mice of each STAT family protein displayed defective responses to cytokines, demonstrating an important role in cytokine-mediated biological responses. However, unlike the mice lacking other STAT proteins, Stat3-deficient mice died during their early embryogenesis. Therefore, in an attempt to avoid the lethality and assess the role of Stat3 in cytokine-mediated functions in mouse adult tissues, conditional gene targeting utilizing a Cre-loxP system was achieved. By this method, Stat3 was disrupted in several types of tissue, including T cells, macrophages, skin, and mammary gland. Analyses of these Stat3-mutant mice revealed important roles of Stat3 in biological functions in each tissue.

Keywords

EN

CONDITIONAL GENE TARGETING; CYTOKINE; SIGNAL TRANSDUCTION; STAT3

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2001
• Volume: 49
• Issue: 4
• Pages: 279-284

Contributors

author

K. Takeda

author

S. Akira

• Document Type: REVIEW
• Publication order reference: K. Takeda, Department of Host Defense, Research Institute for Microbial Diseases, and CRSET of Japan Science and Technology Corporation, Osaka University, 3-1 Yamada-oka, Suita, Osaka 565-0871, Japan