PL EN


Preferences help
enabled [disable] Abstract
Number of results
1997 | 57 | 3 | 203-208
Article title

Photochemically-induced vascular damage in brain cortex. Transmission and scanning electron microscopy study

Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
Morphological changes of microvessels of cerebral cortex were evaluated in a model of cerebral infarction initiated by a photochemical reaction. Rats were treated with intravenous injection of rose Bengal and irradiated from a halogen lamp source through an intact cranium to precipitate microvascular damage. Investigations in transmission and scanning electron microscopy revealed platelet aggregation on endothelial cells preceded by its early ultrastructural damage. Other typical microscopic features of brain ischaemic injury were present suggesting that the present method may be used as a model for investigating ischaemic brain damage. Since the photochemical activation of the rose Bengal dye results in formation of reactive oxygen species this model may be particularly useful to elucidate the role of free radical-mediated endothelial damage in the formation of microthrombi and blood-brain-barrier integrity.
Publisher

Year
Volume
57
Issue
3
Pages
203-208
Physical description
Contributors
References
Document Type
article
Publication order reference
B.Gajkowska, Laboratory of the Ultrastructure of the Central Nervous System, Medical Research Centre, Polish Academy of Sciences,5 Pawinski St., 02-106 Warsaw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-cf3d831b-22d8-35ec-84e3-66b10550925b
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.