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2000 | 48 | 5 | 529-537
Article title

The therapeutic potential of interleukin 10 in infection and inflammation

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Languages of publication
EN
Abstracts
EN
Interleukin 10 (IL-10), a cytokine with inhibitory activity on inflammation and cell -mediated immune responses (CMIR), holds enormous potential for the treatment of inflammatory and autoimmune disorders. In addition, IL-10 has also been implicated in the immunopathogenesis of a number of infectious diseases through the use of IL-10 knock-out or IL-10 transgenic mouse models. In this review, we delineate infectious and inflammatory conditions in which IL-10 has shown potential for therapeutic manipulation. Specifically, we review the role of IL-10 in human endotoxemia/sepsis and in HIV infection, conditions for which preliminary phase I trials have recently been undertaken. It is suggested that the therapeutic potential of IL-10 to selectively ameliorate human infectious and inflammatory processes can be realized through a careful selection of the clinical conditions in which patients are undergoing concomitant treatment with anti-microbial regimens.
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Year
Volume
48
Issue
5
Pages
529-537
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Contributors
author
author
References
Document Type
REVIEW
Publication order reference
A. Kumar, Department of Pediatrics, University of Ottawa, Ontario, Canada
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-ce797e6c-22b6-3fb4-8741-8aad89c0fb12
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