PL EN


Preferences help
enabled [disable] Abstract
Number of results
2006 | 66 | 4 | 279-291
Article title

Neural commitment of cord blood stem cells (HUCB-NSC/NP): Therapeutic perspectives

Selected contents from this journal
Title variants
Languages of publication
EN
Abstracts
EN
Human umbilical cord blood (HUCB) is considered a promising source of neural progenitors capable of being used for cellular therapies in neurological disorders. Here we review briefly our work on the elucidation of mechanisms and development of practical standards as regards the selection, maintenance and use of cord blood derivatives for such purposes. Our results join those of other recent studies in suggesting strongly that, the generation of neural-like cells from tissue belonging to a different germ layer (such as a cord blood is) is most probably explained by reference to a discrete subpopulation of embryonic-like stem cells of pluripotent characteristics. Such cells identified in cord blood through their expression of specific genetic and protein markers can be expanded in vitro and directed toward neurally-committed progenitors differentiating further into more mature neuron-like or macroglia-like cell phenotypes. From this HUCB-derived neural progenitor fraction a novel neural-like stem cell line (HUCB-NSC) has been developed, and characterized in respect of in vitro and in vivo (post-transplantation) properties.
Contributors
author
author
author
References
Document Type
ARTICLE
Publication order reference
Krystyna Domanska-Janik, Neuro-Repair Department, Medical Research Center, Polish Academy of Sciences, ul. Pawinskiego 5, 02-106 Warsaw, Poland
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-cde14474-a1d5-3b21-851e-6f7997018e06
JavaScript is turned off in your web browser. Turn it on to take full advantage of this site, then refresh the page.