Fraction of spleen cells responsible for suppresion of cellular immune response to SRBC in mice treated with outer membrane proteins of Shigella
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Effect of splenocytes isolated from mice immunized with suppressive dose of OMP rfom Shigella on delaed hipersensivity, induced in mice with sheep red blood cells was investigated. Only the population of T lymphocytes was found to suppress the delayed hypersensitivity, as measured by the footpad reaction. The results suggest that OMP of Shigella are able to induce in the spleen of animals active T cells which are responsible for the suppression of cellular response induced by SRBC.
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