Exuberant cellular reaction of the optic nerves in experimental Creutzfeldt-Jakob disease

• Authors: P.P. Liberski , B. Sikorska , J. Bratosiewicz-Wasik , A. Walis , P. Brown , D. Brown
• Languages of publication: EN

Abstracts

EN

We report here on the exuberant glial reaction in the optic nerves affected by prion diseases. Optic nerves from CJD- and GSS-, and scrapie-infected mice and hamsters showed severe pathology. These lesions were qualitatively indistinguishable from each other but were more intense in the Fujisaki model than in the hamsters inoculated with Echigo-1. Exuberant cellular reaction comprised of macrophages containing numerous mitochondria, abundant rough endoplasmic reticulum, and secondary lysosomes filled with digested myelin debris, electron-dense material and occasionally, entire myelin-bound vacuoles were readily observed in both models. Macrophages actively digesting myelin fragments and containing lyre-like bodies and paracrystalline inclusions were frequently noted. Some macrophages extended long filopodia to form labyrinth-like structures, and within a few macrophages, concentric arrays of cisterns and channels sequestrated part of the cytoplasm. An analogous network of narrow cisterns was seen to surround whole segments of the myelinated fibers.

Keywords

EN

CREUTZFELDT-JAKOB DISEASE; MACROPHAGE; PRION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2003
• Volume: 63
• Issue: 4
• Pages: 309-318

Contributors

author

P.P. Liberski

author

B. Sikorska

author

J. Bratosiewicz-Wasik

author

A. Walis

author

P. Brown

author

D. Brown

• Document Type: article