The effect of vasopressin analog on learning and memory processes in rats with experimental amnesia

• Authors: Halina Car , Maria Borawska , Konstanty Wisniewski
• Languages of publication: EN

Abstracts

EN

We investigated the effect of a single 2 microg dose of a vasopressin (AVP) analog [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP on processes of retrieval, consolidation and acquisition of conditioned reflexes in rats with experimentally induced amnesia. The investigated amnesia models were: long term ethanol intoxication, electroconvulsive shocks (ECS), and hypoxia. They all profoundly impaired the learning and memory processes in all tests used. The AVP analog - [d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP facilitated retrieval of passive avoidance in all amnesia models. It improved consolidation of active avoidance of rats previously treated with alcohol, but did not affect the acquisition of active avoidance.[d(CH2)1/5,Tyr(Me)2,delta3Pro7]AVP lack antidiuretic properties.

Keywords

EN

AMNESIA; RAT; VASOPRESSIN

Discipline

• PHARMACOLOGY: PHARMACOLOGY

• Publisher: Institute of Pharmacology, Polish Academy of Sciences
• Journal: Polish Journal of Pharmacology
• Year: 1993
• Volume: 45
• Issue: 1
• Pages: 11-22

Contributors

author

Halina Car

author

Maria Borawska

author

Konstanty Wisniewski

• Document Type: article