A single compartment neuron model with activity-dependent conductances during NMDA induced activity

• Authors: M. Baszczak , S. Kasicki
• Languages of publication: EN

Abstracts

EN

In most neuron models the values of maximal conductances of membrane ionic currents are fixed. In our paper we investigate spiking activity of the neuron model activated tonically by NMDA synapse, when the membrane ionic currents are dynamically dependent on calcium concentration, as in a model by Abbott and coauthors (1993). A spiking neuron model (in Matlab/Simulink environment) is based on the properties of lamprey spinal neurons. The basic neuron is a one-compartment model with voltage-gated Na+, K+, Ca2+, KCa+ channels. The Na+ and K+ currents are described with the dynamic equations of Hodkin-Huxley model (Hodgkin and Huxley 1952). The Ca2+ and KCa+ channels are modeled using description of calcium dynamic introduced by Ekeberg and coauthors (1991). The model was tonically activated by NMDA synapse, described by a kinetic model of synaptic transmission. We analyzed the activity of this model and showed that when only one of conductances is calcium-dependent, the cell is not able to react to and recover from external perturbations.

Keywords

EN

CONDUCTANCE; MODEL NEURON; SYNAPTIC DRIVE

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2005
• Volume: 65
• Issue: 2
• Pages: 183-190

Contributors

author

M. Baszczak

author

S. Kasicki

• Document Type: SHORT COMMUNICA
• Publication order reference: Stefan Kasicki, Department of Neurophysiology, Nencki Institute of Experimental Biology, Polish Academy of Sciences, 3 Pasteur St., 02-093 Warsaw, Poland