Effects of growth hormone on neuroendocrine function
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Although the role og growth hormone (GH) in the control of reproductive functions is not well understood, there is considerable evidence that the states of both GH deficiency and GH excess are typically associated with reproductive deficits.To identify the possible involvement of functinal alternations in the hypothalmic-pituitary system in producing these deficits, we are studying neuroendocrine function related to reproduction in transgenic animals overexpressing GH, in animals with congenital GH deficiency, and in animals with selective immunonoutralization of GH.The results indicate that GH acts on the hypothalmus to alter dopaminergic and noradrenergic control of prolactin and gonadotrophin release.Life-long elevation of GH levels outside the physiological range disrupts feedback control of luteininzing hormone (LH) relaese by gonadal steroids.Plasma LH and follicle-stimulating hormone (FSH) levels and feedback control of LH release are also abnormal in GH-deficient animals indicating that physiologival levels of endogenous GH are normally involved in the control of gonadotropin release.Differences between the effects of bovine vs.human GH in transgenic moce and differential effects of GH mechanisms involved in the actions of HG on the hypothalmic-pituitary system.
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