V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?

• Authors: R. Golub
• Languages of publication: EN

Abstracts

EN

Lymphocyte can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.

Keywords

EN

GENE REARRANGEMENT; IMMUNOGLOBULIN; LYMPHOCYTE

Discipline

• IMMUNOLOGY: IMMUNOLOGY

• Publisher: Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences
• Journal: Archivum Immunologiae et Therapiae Experimentalis
• Year: 2002
• Volume: 50
• Issue: 4
• Pages: 255-262

Contributors

author

R. Golub

• Document Type: REVIEW
• Publication order reference: R. Golub, Unite du Developpement des Lymphocytes, Institut Pasteur, 75724 Paris Cedex 15, France