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2002 | 50 | 4 | 255-262
Article title

V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?

Authors
Title variants
Languages of publication
EN
Abstracts
EN
Lymphocyte can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.
Publisher

Year
Volume
50
Issue
4
Pages
255-262
Physical description
Contributors
author
References
Document Type
REVIEW
Publication order reference
R. Golub, Unite du Developpement des Lymphocytes, Institut Pasteur, 75724 Paris Cedex 15, France
Identifiers
YADDA identifier
bwmeta1.element.element-from-psjc-c40f94db-46d4-3963-9c12-b3586e2b33b8
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