V gene replacement in T and B lymphocytes: illicit or regimented rearrangement?
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Lymphocyte can undergo novel types of secondary genetic rearrangements that alter the specificity of a pre-existing B cell receptor (BCR) or T cell receptor (TCR). V gene replacement is one of them and it replaces an already rearranged V gene segment with an upstream germline V gene segment. This review focuses on the molecular aspect of rearrangement. The role of this mechanism in the immune system is debated.
Publication order reference
R. Golub, Unite du Developpement des Lymphocytes, Institut Pasteur, 75724 Paris Cedex 15, France