Effect of carvedilol on neuronal survival and poly(ADP-ribose) polymerase activity in hippocampus after transient forebrain ischemia

• Authors: R. Strosznajder , H. Jesko , J. Dziewulska
• Languages of publication: EN

Abstracts

EN

Carvedilol a beta-adrenoreceptor antagonist with potent antioxidant properties raises high expectations in therapy of ischemia. In this study the effect of carvedilol on neuronal survival after transient forebrain ischemia in gerbils was investigated. The role of poly(ADP-ribose) polymerase (PARP-1) in this process was evaluated. Our data indicated that carvedilol administered subcutaneously in a dose of 7 or 70 mg/kg b.w. directly after 5 min of transient forebrain ischemia protects significant population of neurons in hippocampal area CA1, but has no effect after induction of prolonged 10 min ischemia. Carvedilol significantly decreased PARP activity in hippocampus that was markedly increased after both 15 min and 4 days of reperfusion following 5 min of ischemia. Moreover, carvedilol prevented NAD+ depletion after ischemic-reperfusion insult. These results indicated that carvedilol protects neurons against death and suggested that suppression of PARP activity during reperfusion could be involved in this process.

Keywords

EN

BETA-ADRENORECEPTOR; ISCHEMIA; NEUROPROTECTION; PARP; REPERFUSION

Discipline

• EXPERIMENTAL_BIOLOGY_&_MEDICINE: EXPERIMENTAL BIOLOGY & MEDICINE

• Publisher: Marceli Nencki Institute of Experimental Biology, Polish Academy of Sciences
• Journal: Acta Neurobiologiae Experimentalis
• Year: 2005
• Volume: 65
• Issue: 2
• Pages: 137-134

Contributors

author

R. Strosznajder

author

H. Jesko

author

J. Dziewulska

• Document Type: ARTICLE
• Publication order reference: Robert P. Strosznajder, Department of Respiratory Research, Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland