Some aspects of the influence of endothelin on renal function
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Peptides from endothelin family (ET-1, ET-2, ET-3), synthetized by the endothelian cells, are now known to exers diversae biological effects on wide variety of cell types and tissues mainly through two subtypes of receptors (A- and B-type ET receptors). Tissue distribution and mechanism of action of ET peptides and their receptors are reviewed.The biological role of ET peptides and receptors in health as well as in renal diseases is discussed.
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