Neuroendocrine mechanism mediating fasting-induced suppression of luteinizing hormone secretion in female rats
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Forty-eight hours fasting profoundly supresses LH secretion in female rats.The following neural pathway mediating fasting-induced suppression of LH secretion has been suggested by a series of experiment:a signal associated with fasting emanting from the upper digestive tract reaches the A2 region in the medulla oblongata via afferent vagal nerve so as to activate the noradrenergic pathway projecting to the hypothalmic paraventricular nucleus (PVN); this results in an increased corticotropin-releasing hormone release to suppress LHRH release and than LH release.The PVN and A2 region of the medulla oblongata are the estogen feedback sites to activate the above-mentioned neural pathway.The estrogen feedback action on the PVN and A2 region is considered to be due to an increased expression of estrogen receptors in these nuclei after 48-h fasting.The response of gonadal axis during fasting could be due to the changes in some nutrients, such as glucose and free-fatty acids.In this context, malnutration could be a kind of stress accompanied by an increased feeding behavior and decresed gonadal activity.
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